HCN4

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 is a protein that in humans is encoded by the HCN4 gene.

There are four HCN channels. HCN4 is prominently expressed in the pace maker region of the mammalian heart. Some humans with bradycardia and Sick sinus syndrome have been shown to have mutations in their HCN4 gene. The role of HCN channels in autonomic control of heart rate is currently a matter of ongoing investigation.

Interactions

HCN4 has been shown to interact with HCN2.

See also

• Cyclic nucleotide-gated ion channel
• Funny current

References

Further reading

External links

• GeneReviews/NIH/NCBI/UW entry on Brugada syndrome
• HCN4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• HCN4 human gene location in the UCSC Genome Browser.
• HCN4 human gene details in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.