Elisabeth of Hesse (13 February 1539 – 14 March 1582) was a German noblewoman, by birth member of the House of Hesse and by virtue of marriage Electress of Pfalz-Simmern. Sie starb (an einem – wie aus Briefen und Konsilien Marius’ an Elisabeths Ehemann Kurfürst Ludwig VI. hervorgeht – mit schmerzlosem Eiter- und Blutausfluss aus dem Darm verbundenen Leiden) schon ein Jahr vor ihrem Ehemann und wurde am 1. April 1582 in der Church of the Holy Spirit (Heidelberg).
She was born as the seventh child and fourth daughter of Philip I, Landgrave of Hesse and his wife, Duchess Christine of Saxony, daughter of George, Duke of Saxony.
On 8 July 1560 she married Louis VI, Elector Palatine. They had the following children:
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