CD43

Leukosialin also known as sialophorin or CD43 (cluster of differentiation 43) is a transmembrane cell surface protein that in humans is encoded by the SPN (sialophorin) gene.

Function

Sialophorin (leukosialin) is a major sialoglycoprotein on the surface of human T lymphocytes, monocytes, granulocytes, and some B lymphocytes, which appears to be important for immune function and may be part of a physiologic ligand-receptor complex involved in T-cell activation.

Clinical significance

Defects in the CD43 molecule are associated with the development of Wiskott–Aldrich syndrome. It also appears in about 25% of intestinal MALTomas. Using immunohistochemistry, CD43 can be demonstrated in the paracortical T-cells of healthy lymph nodes and tonsils; it is also positive in a range of lymphoid and myeloid tumours. Although it is present in over 90% of T-cell lymphomas, it is generally less effective at demonstrating this condition than is CD3 antigen. However, it may be useful as part of a panel to demonstrate B-cell lymphoblastic lymphoma, since the malignant cells in this condition are often CD43 positive, and may be difficult to stain with other antibodies. Because it stains granulocytes and their precursors, it is also an effective marker for myeloid tumours.

Interactions

CD43 has been shown to interact with EZR and Moesin.

References

Further reading

External links

• CD43+antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human SPN genome location and SPN gene details page in the UCSC Genome Browser.

1. SPN
2. Wiskott–Aldrich syndrome
3. The Attack (band)
4. List of minor planets: 48001–49000
5. Daniel O. Griffin
6. Peptidoglycan
7. Mucin
8. Proteoglycan
9. Glycoprotein
10. P-selectin glycoprotein ligand-1
11. CD68
12. Glycoconjugate
13. PD-L1
14. T cell
15. Marginal zone lymphoma
16. Cluster of differentiation
17. CD4
18. Kell antigen system
19. PTPRC
20. CD3 (immunology)