Profilin 1

Profilin-1 is a protein that in humans is encoded by the PFN1 gene.

Function

The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome. Mutations in this gene may be a rare cause of amyotrophic lateral sclerosis, also called Lou Gehrig's disease.

Interactions

Profilin 1 has been shown to interact with:

• FMNL1,
• MLLT4
• Vasodilator-stimulated phosphoprotein,
• WASF1, and
• WASL.

References

Further reading

1. Profilin
2. Microfilament
3. Keratin
4. Stress granule
5. Catenin beta-1
6. Troponin I
7. Troponin
8. Troponin T
9. Tau protein
10. Fibrillin
11. Titin
12. Actin
13. Tubulin
14. Dystrophin
15. Kinesin
16. Microtubule
17. Desmin
18. Myosin
19. Lamin
20. Alpha-actinin-3